Found 9 hits for monomerid = 5491,5566,5470,5471,5485 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cyclin-A2 [171-432]/Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM5566
(2,6-Diamino-4-cyclohexylmethoxy-5-nitrosopyrimidin...)Show InChI InChI=1S/C11H17N5O2/c12-9-8(16-17)10(15-11(13)14-9)18-6-7-4-2-1-3-5-7/h7H,1-6H2,(H4,12,13,14,15) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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DrugBank MCE MMDB PC cid PC sid PDB UniChem
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| MMDB PDB Article PubMed
| 1.30E+3 | -8.16 | n/a | n/a | n/a | n/a | n/a | 7.5 | 30 |
University of Newcastle
| Assay Description The enzyme was assayed with substrate histone H1 in the presence of 12.5 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which inhibits ... |
J Med Chem 43: 2797-804 (2000)
Article DOI: 10.1021/jm990628o BindingDB Entry DOI: 10.7270/Q20R9MKP |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Cyclin-A2 [171-432]/Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM5485
(6-(cyclohexylmethoxy)-9H-purin-2-amine | CHEMBL269...)Show InChI InChI=1S/C12H17N5O/c13-12-16-10-9(14-7-15-10)11(17-12)18-6-8-4-2-1-3-5-8/h7-8H,1-6H2,(H3,13,14,15,16,17) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL MCE MMDB PC cid PC sid PDB UniChem
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| MMDB PDB Article PubMed
| 1.20E+4 | -6.82 | n/a | n/a | n/a | n/a | n/a | 7.5 | 30 |
University of Newcastle
| Assay Description The enzyme was assayed with substrate histone H1 in the presence of 12.5 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which inhibits ... |
J Med Chem 43: 2797-804 (2000)
Article DOI: 10.1021/jm990628o BindingDB Entry DOI: 10.7270/Q20R9MKP |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Cyclin-A2 [171-432]/Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM5485
(6-(cyclohexylmethoxy)-9H-purin-2-amine | CHEMBL269...)Show InChI InChI=1S/C12H17N5O/c13-12-16-10-9(14-7-15-10)11(17-12)18-6-8-4-2-1-3-5-8/h7-8H,1-6H2,(H3,13,14,15,16,17) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Newcastle
| Assay Description The enzyme was assayed with substrate histone H1 in the presence of 12.5 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which inhibits ... |
J Med Chem 45: 3381-93 (2002)
Article DOI: 10.1021/jm020056z BindingDB Entry DOI: 10.7270/Q2891424 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Cyclin-A2 [171-432]/Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM5491
(6-(benzyloxy)-9H-purin-2-amine | CHEMBL407874 | O6...)Show InChI InChI=1S/C12H11N5O/c13-12-16-10-9(14-7-15-10)11(17-12)18-6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H3,13,14,15,16,17) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Newcastle
| Assay Description The enzyme was assayed with substrate histone H1 in the presence of 12.5 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which inhibits ... |
J Med Chem 45: 3381-93 (2002)
Article DOI: 10.1021/jm020056z BindingDB Entry DOI: 10.7270/Q2891424 |
More data for this Ligand-Target Pair | |
Cyclin-A2 [171-432]/Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM5566
(2,6-Diamino-4-cyclohexylmethoxy-5-nitrosopyrimidin...)Show InChI InChI=1S/C11H17N5O2/c12-9-8(16-17)10(15-11(13)14-9)18-6-7-4-2-1-3-5-7/h7H,1-6H2,(H4,12,13,14,15) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | 7.5 | 30 |
University of Newcastle
| Assay Description The enzyme was assayed with substrate histone H1 in the presence of 12.5 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which inhibits ... |
Bioorg Med Chem Lett 13: 3079-82 (2003)
Article DOI: 10.1016/s0960-894x(03)00651-6 BindingDB Entry DOI: 10.7270/Q2R78CDT |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Cyclin-A2 [171-432]/Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM5566
(2,6-Diamino-4-cyclohexylmethoxy-5-nitrosopyrimidin...)Show InChI InChI=1S/C11H17N5O2/c12-9-8(16-17)10(15-11(13)14-9)18-6-7-4-2-1-3-5-7/h7H,1-6H2,(H4,12,13,14,15) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | 7.5 | 30 |
University of Newcastle
| Assay Description The enzyme was assayed with substrate histone H1 in the presence of 12.5 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which inhibits ... |
J Med Chem 43: 2797-804 (2000)
Article DOI: 10.1021/jm990628o BindingDB Entry DOI: 10.7270/Q20R9MKP |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Cyclin-A2 [171-432]/Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM5471
(6-ethoxy-9H-purin-2-amine | CHEMBL406419 | O6-Subs...)Show InChI InChI=1S/C7H9N5O/c1-2-13-6-4-5(10-3-9-4)11-7(8)12-6/h3H,2H2,1H3,(H3,8,9,10,11,12) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Newcastle
| Assay Description The enzyme was assayed with substrate histone H1 in the presence of 12.5 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which inhibits ... |
J Med Chem 45: 3381-93 (2002)
Article DOI: 10.1021/jm020056z BindingDB Entry DOI: 10.7270/Q2891424 |
More data for this Ligand-Target Pair | |
Cyclin-A2 [171-432]/Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM5470
(6-methoxy-9H-purin-2-amine | CHEMBL226395 | O6-Sub...)Show InChI InChI=1S/C6H7N5O/c1-12-5-3-4(9-2-8-3)10-6(7)11-5/h2H,1H3,(H3,7,8,9,10,11) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Newcastle
| Assay Description The enzyme was assayed with substrate histone H1 in the presence of 12.5 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which inhibits ... |
J Med Chem 45: 3381-93 (2002)
Article DOI: 10.1021/jm020056z BindingDB Entry DOI: 10.7270/Q2891424 |
More data for this Ligand-Target Pair | |
Cyclin-A2 [171-432]/Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM5485
(6-(cyclohexylmethoxy)-9H-purin-2-amine | CHEMBL269...)Show InChI InChI=1S/C12H17N5O/c13-12-16-10-9(14-7-15-10)11(17-12)18-6-8-4-2-1-3-5-8/h7-8H,1-6H2,(H3,13,14,15,16,17) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | 7.5 | 30 |
University of Newcastle
| Assay Description The enzyme was assayed with substrate histone H1 in the presence of 12.5 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which inhibits ... |
J Med Chem 47: 3710-22 (2004)
Article DOI: 10.1021/jm0311442 BindingDB Entry DOI: 10.7270/Q24J0C9Z |
More data for this Ligand-Target Pair | 3D Structure (crystal) |